Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 08, Issue 1, 2006; Page No.(13-15)

DETECTION OF TOXOPLASMA GONDII ANTIBODY FOR DIAGNOSIS OF OCULAR TOXOPLASMOSIS

F. MALEKI AND H. SADRI

Abstract

Forty patients with cataracts, as well as 40 patients with proven ocular toxoplasmosis were enrolled in this prospective clinical study. Serum IgG and aqueous IgG in both groups were measured by enzyme linked immunosorbent assay (ELISA) and the corresponding rations were calculated. Serum IgG/ Aqueous humor IgG ratio was less then 100 in the patient group and more then 100 in the control group. On the other hand in the chorioretinitis subgroup the ratio was less 13, while in the group with uveitis, the Serum IgG (antitoxo) ratio was more then 13 (P<0.05). The results revealed that calculating the ratio = /AqueousIgG (antitoxo) may be helpful as an adjunet to diagnosis in cases with clinically atypical ocular toxoplasmosis.

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