IN VITRO AND IN VIVO INHIBITION OF BRAIN ACETYLCHOLINESTERASE OF CATLA CATLA (HAM) AND OREOCHROMIS MOSSAMBICLIS (PETERS) BY MALATHIONR. MATHIVANANAbstract Acetylcholinesterase (AchE) activit) in brain homogenates of Calla catla and Oreochroinis mossambicus was estimated under optimal conditions at different concentrations (0, 3, 6, 9, 12, 15 ppm) of malathion in vitro. Using regression equation, the 150 value was obtained as 6.3 ppm and 6.8 ppm for C.catla and 0.mossambicus respectively. The 1,0 value was chosen as exposure concentration for in vivo studies. Time taken for 50% inhibition in vivo was 192 and 224 mts for C.catla and 0.mossambicus, respectively. 0.rnossambicus appears to have better barrier system than that of C.catla.
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