Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 08, Issue 1, 2006; Page No.(165-166)

RADIOSENSITIZING EFFECT OF PARACETAMOL WITH BIOLOGICAL METAL IONS IN THIOBACILLUS FERROOXIDANS

P.M. DONGIZE AND VIJAY KHOLE

Abstract

Effect of paracetamol with biological metal ions viz, calcium, magnesium, copper and zinc was studied on Thiobacillus ferrooxidans cellular membrane system Concentration dependent racliosensitization was exhibited by paracetamol. However, reduction in radiosensitization was observed combination of all biological ions. DMF in paracetamol (0.075 mM), (0.10 mM), (0.125 mM) was 1.111, 1.666, 3.888 respectively. Paracetamol (0.125 mM) with calcium, magnesium, copper and zinc was 2.000, 1.428, 2.222, 1.818 respectively. The nature of interaction of paracetamol with biological metal ions is discussed at cellular membrane level of Thiobacillus ferrooxidans.

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