Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 8, Issue 3, 2006; Page No.(503-508)

COMPARISON OF ANTIBACTERIAL ACTIVITIES OF SOME NATURAL AND SYNTHETIC COMPOUNDS

RATHISH NAIR, ANJANA SHAH, SHIPRA BALUJA AND SUMITRA CHANDA

Abstract

This study describes the antibacterial activity of two natural and eight synthetic compounds. The two natural compounds were the leaves of Punica granatum and Maytenus emargmata . The eight synthetic compounds were Schiff bases derived from sulfonamide, 4-amino antipyrene and raceacetophenone. Both natural and synthetic compounds were screened for antibacterial activity against few clinical isolates (isolated from Urine, Blood, Tracheal secretion and Pus). The Schiff bases produced were 1) 4[2-aza-2- (2-chlorophenyl) vinyl] benzene sulfonamide [AD1] (2) 4[2-aza-2- (2-hydroxyphenyl) vinyl] benzene sulfonamide [AD21 (3) [1-aza-4-phenylbuta-1, 3-dienyl] benzene sulfonamide [AD3] (4) 4-[1-aza-2- (2-chlorophenyl) vinyl] 2, 3- diinethyl- 1-pheny1-3-pyrazolin-5-one [AS1] (5) 441-aza2- (2- hydroxyphenyl) vinyl]- 2, 3-dimethy1-1-phenyl-3- pyrazolin.-5-one [AS2] (6) 441-aza-4-phenylbuta1, 3-dienyl] 2,3-dimethy1-1-phenyl-3-pyrazolin-5-one [A.S3] (7) 4[2-aza-1 -methyl-2- (2-nitro_p henyl) viny1]-6-ethylbenzene1l3_3-diol [ADS1] (8) 4[2-aza-2- (5-ehty1-2, 4-dihydroxyphenyl) prop-1-enyll benzene sulfonamide [ADS2]. Extracts of these compounds (both natural and synthetic) were tried on 5 pathogenic [E. coli, Pseudomonas aeruginosa¬ĄDroteus znilgaris, Klebstella pneuinonias and Staphylococcus aureusl strains. The antibacterial activity was evaluated by the Agar Ditch method, Both natural and synthetic compounds were extracted in DMF (polar) and 1,4 Dioxan (non polar). Among the medicinal plants studied, P.granatum showed strong activity against K.pneumoniae, S.aureus and P.aeruginosa but showed moderate activity against E.coli and P.vulgaris while lvf.emarginata showed strong activity against K.pneumoniae, S.aureus and E.coli but showed moderate activity against P.aeruginosa. and P.vulgaris. Amongst the two natural compounds P. granatum was better than M. emarginata; while amongst the synthetic compounds, sulfonamide moiety with Cinnamaldehyde side chain (ADS) proved to be the best. The non-polar solvent 1,4 Dioxan proved to be the best. It appears that some of these natural and synthetic compounds with particular structure cold be used as a lead molecule in drug designing to combat the diseases caused by these bacteria.

Enter your contact information below to receive full paper.
Your Name :
Email:
Phone:
City:
Cost of Full Paper: Rs.75 for Indian Nationals or $20 (USD) for international subscribers.
By clicking on Request Paper you Agree to pay the above mentioned cost per paper.
  
Journal Issues
Vol 20, Dec. Suppl. No.2, 2018
Vol 20, Issue 4, 2018
Vol 20, Dec. Suppl. Issue, 2018
Vol 20, Oct Suppl. Issue, 2018
Vol 20, Issue 3, 2018
Vol 20, Issue 2, 2018
Vol 20, Issue 1, 2018
Vol 20, Feb. Suppl. Issue, 2018
Vol 19, Issue 4, 2017
Vol 19, Nov. Suppl, Issue 2017
Vol 19, Issue 3, 2017
Vol 19, Issue 2, 2017
Vol 19, Issue 1, 2017
Vol 18, Issue 4, 2016
Vol 18, Issue 3, 2016
Vol 18, Issue 2, 2016
Vol 18, Issue 1, 2016
Vol 17, Issue 4, 2015
Vol 17, Issue 3, 2015
Vol. 17 Special Issue 2015
Vol 17, Issue 2, 2015
Vol 17, Issue 1, 2015
Vol 16, Issue 4, 2014
Vol 16, Issue 3, 2014
Vol 16, Issue 2, 2014
Vol 16, Issue 1, 2014
Vol 15, Issue 4, 2013
Vol 15, Issue 3, 2013
Vol 15, Issue 2, 2013
Vol 15 Issue 1, 2013
Vol 14, Issue 4, 2012
Vol 14, Issue 3, 2012
Vol 14, Issue 2, 2012
Vol.14, Issue 1, 2012
Vol.13, Issue 4, 2011
Vol.13, Issue 3, 2011
Vol.13, Issue 2, 2011
Vol.13, Issue 1, 2011
Vol.12, Issue 4, 2010
Vol.12, Issue 3, 2010
Vol.12, Issue 2, 2010
Vol.12, Issue 1, 2010
Vol 11, Issue 4, 2009
Vol 11, Issue 3, 2009
Vol 11, Issue 2, 2009
Vol 11, Issue 1, 2009
Vol 10, Issue 4, 2008
Vol 10, Issue 3, 2008
Vol 10, Issue 3, 2008
Vol 10, Issue 2, 2008
Vol 10, Issue 1, 2008
Vol 9, Issue 4, 2007
Vol 9, Issue 3, 2007
Vol 9, Issue 2, 2007
Vol 9, Issue 1, 2007
Vol 8, Issue 4, 2006
Vol 8, Issue 3, 2006
Vol 08, Issue 2, 2006
Vol 08, Issue 1, 2006
Vol 7 Issue 4, 2005
Vol 07, Issue 3, 2005
Vol 07, Issue 2, 2005
Vol 6 Issue 4, 2004
Vol 6 Issue 3, 2004
Vol 6 Issue 2, 2004
Vol 6 Issue 1, 2004
Vol 5 Issue 3, 2003
Vol 5 Issue 2, 2003
Vol 04, Issue 4, 2002
Vol 04, Issue 1, 2002
Vol 3 Issue 1-2, 2001
Vol 1 Issue 1-2, 2000
Vol 1 Issue 3-4, 1999
Vol 1 Issue 1-2, 1999
Looking for Past Issues? Click here to get them!!