IMPACT OF CADMIUM CHLORIDE ON THE CHOLINERGIC SYSTEM IN THE BRAIN OF RATK. YELLAMMA, P. VENKATAKRISHNA REDDY AND U. SREEHARIAbstract In the present study, the cholinergic system of different brain areas showed variable sensitivity to cadmium chloride stress. In both acute and chronic dose studies the enzyme acetylcholine esterase was inhibited significantly in all the areas. During acute dose studies maximum inhibition was noticed at 12th in all the brain areas, while in chronic dose studies peak inhibition was noticed on 7th day and recovery towards normalcy was noticed in all the areas after 11th day onwards. On the contrary, elevation in Ach content was noticed in all the areas. In acute dose studies striatum and cortex showed maximum elevation at 3h, hippocampus, cerebellum and pons medulla at 12h. But in chronic dose studies accumulation of acetyl choline gradually progressed till 7th day and thence a recovery trend was observed. Thus the changes in cholinergic system testify the differential sensitivity to cadmium chloride stress.
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