THE PATHOGENESIS OF EXPERIMENTAL AFLATOXICOSIS ON PROTEIN AND DNA CONTENT OF LIVER IN BROILERSP. J. R. NATHANAEL AND V.V. VARDHANIAbstract In recent years, Aspergillus species, particularly Aspergillus flavus, has been increasingly recognized in infections and hypersensitivity diseases in man and broilers. The clinical symptoms of these diseases are dependent upon the immunological status of the subject. Few reports are available in the literature on the pathogenicity of Aspergillus species to different laboratory animals such as mice, rats, rabbits and broilers. The present study was designed to study the protein and DNA content in the liver of broilers infected with aflatoxin B1 (AFB1). Four groups, (A, B, C and D) of broilers were infected with various doses of AFB1 orally. Animals were sacrificed at 1, 3, 8 and 11 days of infection and their organs (liver) were removed. The organs were weighed, homogenized and tissue samples were used for the estimation of proteins and DNA. The result clearly demonstrates that aflatoxicosis is able to induce varied changes in the content of proteins and DNA (in liver) in all the experimental groups of broilers though out the infection period.
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