THE IMPACT OF TRIMETHOPRINI ON ASCORBIC ACID CONTENTS OF VARIOUS TISSUES OF THE FRESHWATER MUSSEL, PARREYSIA CYLINDRICA (ANNANADALE AND PRASHAD)H.P. NAGPURE AND S.P. ZAMBAREAbstract For normal growth and several physiological functions, vitamins are required in trace amount. Ascorbic acid, a water-soluble vitamin, is synthesized in most of the animals endogenously but not in case of human beings and other primates. An experimental model, the freshwater bivalve, Parreysia cylindrica (Annandale and Prashad) was exposed to trimethoprim, one of the ingredients of sulfa drug. The bivalves were exposed to acute (136.29 PPM) dose upto 96 hours and chronic (27.25 PPM) dose upto 21 days. The ascorbic acid contents were estimated after 24 and 96 hours of acute and 7, 14 and 21 days of chronic exposure in mantle, gill, foot, testis, ovary, whole body and digestive gland. The level of ascorbic acid showed an overall decrease in most of the tissues except gills while whole body and ovary were the most suffered organs after acute treatment. The foot showed increased ascorbic acid contents and the rest of tissues showed decrease in the ascorbic acid contents, among which maximum decrease was in the gills.
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