EFFECT OF AVIAN INTERLEUKIN -2 ON HUMORAL AND CELL MEDIATED IMMUNE RESPONSES IN CHICKEN VACCINATED AGAINST NEWCASTLE DISEASE VIRUSM. NARSI REDDY, PRALHAD UBHALE, Y. HARI BABU, B. NAGAMANI AND S. VENKATESHWAR 'Abstract An experiment was conducted to determine the adjuventicity of avian IL-2 administered in conjunction with NDV vaccination in chickens. Seventy, day-old commercial layer chicks were divided into three groups (A, B and C). The 30 chicks in each of group-A and group-B were vaccinated with F strain of Newcastle disease virus by the intraocular and intranasal routes at 7 days and 4 weeks of age, and also with K strain of NDV by the subcutaneous route at 9 weeks while group-C (10 chicks) remained as the unvaccinated control. The chicks in group-A (treatment group) were given interieukin-2 (IL-2) @2.5 pg/kg body weight per day by the intramuscular route on 4 consecutive days after each vaccination, while there in group-B remained as vaccinated controls. Blood samples were collected from each bird 6, 12 and 18 days after every vaccination. The humoral immune response, based on HI, SRI[) and SRH, showed was greater in group-A (treatment group) compared to groups B or C. The lymphocyte migration inhibition test (LMIT) was used to assess the cellular immunity. The group-A showed more inhibition of migration compared to groups B or C. The result indicated that IL-2 might be used as an immunornodulator for enhancing immunity against NDV. (Narsi Reddy etal. 2009 Effect of avian interieukin - 2 on humora I and cell mediated immune responses in chicken vaccinated against Newcastle disease virus; I.Bio5ci. 34 00-00).
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