AGE ASSOCIATED ALTERATIONS IN ACETYLCHOLINESTERASE AND MODULATORY EFFECT OF BACOPA MONNIERA (LINN.) ON BRAIN OF MICEMEENA M, PILLAI, SHREYA R. VORA AND RAHUL B. PATILAbstract Bacopa monniera (Linn.) commonly known as Brahmi is well known as medhyarasayana in the traditional system of Ayurveda. It is used to improve memory and intellect since long. It has also been suggested that Brahmi is helpful in treating the nervous disorders related with aging. The present investigation deals with the study of effect of Brahmi on activity of acetyl cholinesterase, in the brain of mice of both sexes during natural aging. It was observed that with the increase in age there was concomitant increase in the level of peroxidation in the brain tissues in both male and female mice. Activity of acetylcholinesterase was found reduced gradually with the advent of age. Treatment of ethanolic extract of Brahmi reduced the peroxidation reactions in brain to a significant level and also elevated the acetylcholinesterase activity in the brain region of male and female mice.
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