Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

STUDY ON THE EFFECT OF DRUGS ON CAENORHABDITIS ELEGANS

SURJO PRABHA PAUL AND SEEBA MANOJ

Abstract

There is an increasing concern about toxicity of wide range of drugs used for treating diseases therefore, a rapid method to determine the effect of these toxic chemicals are warranted. In the present study the toxicity of six drugs were evaluated on model organism Caenorhabditis elegans. The mortality of the nematodes after treatment was adopted as the endpoint for toxicity testing. The LC„ data was calculated and dose responsive curves were obtained. The study revealed that the toxicity was in order of Rivastigimine>Citrizine>Omez>Atenolol>Sodium Valproate>Ampicillin. The LC„ values were then compared with published data of LD„ of rats and mice using Spearman Rank correlation method .The data obtained showed a high positive correlation of toxicity of drugs in C.elegans with rats and mice and hence we demonstrate C. elcgans as a suitable model organism for toxicity testing.