SYNERGISTIC EFFECT OF FIVE MEDICINAL PLANTS ON GLUTATHIONE PEROXIDASE AND REDUCED GLUTATHIONE IN ASTHMATIC MICEKAVITA SHAKYA AND N.P. SHUKLAAbstract The aim of the study was to investigate the effect of five medicinal plant extracts and their synergism on the occurrence of oxidative stress in the liver of mice during asthma by measuring the status of the antioxidant defense system. The extracts were administered orally and their effect on glutathione peroxidase (GPx) and reduced glutathione (GSH) were estimated in egg albumin induced mice. Alpha tocopherol was used as standard reference drug. A significant increase in the activities of glutathione peroxidase and reduced glutathione was observed in liver on treatment with different concentrations of all the extract with the polyherbal composition showing the highest activity, as comparable to that of the standard. Since the study of induction of the antioxidant enzymes is considered to be a reliable marker for evaluating the antiasthmatic efficacy of the medicinal plant, these findings suggest a possible antiasthmatic role for all the plant extract.
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