Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 20, Issue 3, 2018; Page No.(977-981)

ASSOCIATION OF ALDOSTERONE SYNTHASE C-344T AND 11- HYDROXYSTEROID DEHYDROGENASE G225 GENE POLYMORPHISMS WITH BLOOD PRESSURE

SUPRIYA DWIVEDI, ZAOZIANLUNGLIU GONMEI, *GURUDAYAL SINGH TOTEJA, NIDHI SRIVASTAVA, PRIYANKA GUPTA BANSAL, NITA RADHAKRISHNAN, NAVAL KISHORE VIKRAM AND SPRIHA RAO

Abstract

This study has been carried out in adult population of Kirti Nagar slums of West Delhi. The objective was to identify and investigate the association between CYP11B2 (-344 C/T), CYP11B1 (G225A) polymorphisms and blood pressure of slum population. Genomic DNA was extracted from whole blood using DNA extraction kit. DNA sequencing of amplified PCR product were used to identify the – 344 C/T in the CYP11B2 and G225A in CYP11B1 gene variant by using specific primer. In CYP11B2 gene sequence, CC, CT and TT genotypes accounted for 13.3%, 40.3%, and 46.7% in hypertensive cases and 22.2%, 33.3%, and 44.5% in control cases. Among hypertensive cases CT heterozygote was more frequent, whereas C allele was less (33%) and T allele was more (67%) frequent. In CYP11B1 gene sequence, AA, AG and GG genotypes accounted for 26.7%, 40.0%, and 33.3% in hypertensive cases, 11.1%, 33.3%, and 55.5% in control cases. The AG heterozygote was more frequent among the hypertensive subjects. The frequency of the A allele was more (40%) among hypertensive than control (27.8%), however G allele was less frequent among the hypertensive (60%) than control (72.2%). Overall, the distribution of CYP11B1 genotypes and allele frequencies significantly differ between hypertensive and non-hypertensive.

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