Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 20, Dec. Suppl. Issue, 2018; Page No.(48-54)

CLINICAL OUTCOME OF INTRAVENTRICULAR IMPLANTATION AUTOLOGOUS ADIPOSE DERIVED NEURAL PROGENITOR CELLS IN PARKINSON

PURWATI, ASRA AL FAUZI AND PRASTIYA I. GUNAWAN

Abstract

Parkinson’s disease (PD) involves the malfunction and death of vital nerve cells in the brain, is a chronic and progressive movement disorder. Supportive medications and surgery may conduct, but no optimal results have been obtained. The main goal of this study was to investigate the effectiveness of the intraventricular implantation of adipose derived neural progenitor stem cells in post-Parkinson’s disease patients. 12 patients were included in this study. Small adipose tissue was isolated by small lipopectomy under local anesthesia, cultured and derived become neural progenitor cells. Intraventricular implantation was performed in the operating room. The evaluation was carried out using the Unified Parkinson’s Disease Rating Scale (UPDRS), include non-motor experiences and motor experiences of daily living, motor examination, and motor complications. The primary target was the UPDRS over the time period of 12 months after treatment as the end point. Descriptive statistics are provided. 10 of 12 patients (83.33%) had a significant improvement in mentation, behavior and mood, activity of daily living, and motor examination after treatment. There were no serious adverse events reported, limited to mild headaches, fever or vomiting, and all side effects resolved within few days. Because of the small sample size and non-randomised trial performed, we could not reach a definitive conclusion regarding the potential of intraventricular implantation. However, this study shows that repeated intraventricular implantation of autologous stem cells is advantageous.

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