Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 20, Dec. Suppl. Issue, 2018; Page No.(83-87)

THE COMPUTATIONAL STUDY REVEALS THE IMMUNOMODULATORY AND ANTIMICROBIAL EFFECTS OF VERNONIA AMYGDALINA EXTRACT

LIDWINA TRI KRISTANTI SETIAWAN, JUSAK NUGRAHA, WAHYU DEWI TAMAYANTI AND DIDIK HUSWO UTOMO

Abstract

Vernonia amygdalina is known to possess immunomodulatory properties, next to their antimicrobial effects. These immunomodulatory activities could enhance the elimination of bacterial infection. This study aimed to give an overview of the existing evidence from in silico studies on the immunomodulatory and antimicrobial effects of Vernonia amygdalina during bacterial infection. Active compounds from Vernonia amygdalina were extracted from KnapSack database. SMILE format was retrieved from PUBCHEM database. Prediction of Immunomodulatory activity was conducted using PASS SERVER. Molecular mechanism of active compounds in the human body was retrieved from STITCH (Search Tool for Interacting Chemicals) which were experimentally and prediction, then were analyzed computationally. Further Pathway analysis used Cytoscape software. The result showed that there is 35 active compound that found in Vernonia amygdalina. Most of the compounds could act as antimicrobial due to the Probability score (Pa) above 0.3. That score indicated that the specific compounds have potential computationally. It is a novel prediction and should be tested experimentally. The result of pathway analysis showed that myricetin, chlorogenic acid luteolin, androgapanin and andrographolide have a correlation with Akt, mTOR and STAT3 protein that has the main role in inflammation mechanism that related to IL-6 and IL-10. It can be concluded that Vernonia amygdalina has strong antimicrobial activity and could act as immunomodulatory by suppressing Akt protein to reduce IL-6 and activating mTOR and STAT3 protein to regulate IL-10.

Enter your contact information below to receive full paper.
Your Name :
Email:
Phone:
City:
Cost of Full Paper: Rs.75 for Indian Nationals or $20 (USD) for international subscribers.
By clicking on Request Paper you Agree to pay the above mentioned cost per paper.
  
Journal Issues
Vol 20, Dec. Suppl. Issue No.2, 2018
Vol 20, Dec. Suppl. Issue, 2018
Vol 20, Oct Suppl. Issue, 2018
Vol 20, Issue 3, 2018
Vol 20, Issue 1, 2018
Vol 20, Issue 2, 2018
Vol 20, Feb. Suppl. Issue, 2018
Vol 19, Issue 4, 2017
Vol 19, Nov. Suppl, Issue 2017
Vol 19, Issue 3, 2017
Vol 19, Issue 2, 2017
Vol 19, Issue 1, 2017
Vol 18, Issue 4, 2016
Vol 18, Issue 3, 2016
Vol 18, Issue 2, 2016
Vol 18, Issue 1, 2016
Vol 17, Issue 4, 2015
Vol 17, Issue 3, 2015
Vol. 17 Special Issue 2015
Vol 17, Issue 2, 2015
Vol 17, Issue 1, 2015
Vol 16, Issue 4, 2014
Vol 16, Issue 3, 2014
Vol 16, Issue 2, 2014
Vol 16, Issue 1, 2014
Vol 15, Issue 4, 2013
Vol 15, Issue 3, 2013
Vol 15, Issue 2, 2013
Vol 15 Issue 1, 2013
Vol 14, Issue 4, 2012
Vol 14, Issue 3, 2012
Vol 14, Issue 2, 2012
Vol.14, Issue 1, 2012
Vol.13, Issue 4, 2011
Vol.13, Issue 3, 2011
Vol.13, Issue 2, 2011
Vol.13, Issue 1, 2011
Vol.12, Issue 4, 2010
Vol.12, Issue 3, 2010
Vol.12, Issue 2, 2010
Vol.12, Issue 1, 2010
Vol 11, Issue 4, 2009
Vol 11, Issue 3, 2009
Vol 11, Issue 2, 2009
Vol 11, Issue 1, 2009
Vol 10, Issue 4, 2008
Vol 10, Issue 3, 2008
Vol 10, Issue 3, 2008
Vol 10, Issue 2, 2008
Vol 10, Issue 1, 2008
Vol 9, Issue 4, 2007
Vol 9, Issue 3, 2007
Vol 9, Issue 2, 2007
Vol 9, Issue 1, 2007
Vol 8, Issue 4, 2006
Vol 8, Issue 3, 2006
Vol 08, Issue 2, 2006
Vol 08, Issue 1, 2006
Vol 7 Issue 4, 2005
Vol 07, Issue 3, 2005
Vol 07, Issue 2, 2005
Vol 6 Issue 4, 2004
Vol 6 Issue 3, 2004
Vol 6 Issue 2, 2004
Vol 6 Issue 1, 2004
Vol 5 Issue 3, 2003
Vol 5 Issue 2, 2003
Vol 04, Issue 4, 2002
Vol 04, Issue 1, 2002
Vol 3 Issue 1-2, 2001
Vol 1 Issue 1-2, 2000
Vol 1 Issue 3-4, 1999
Vol 1 Issue 1-2, 1999
Vol 205, Issue 4, 2018
Looking for Past Issues? Click here to get them!!