Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 20, Dec. Suppl. No.2, 2018; Page No.(122-127)

THE SINGLE NUCLEOTIDE POLYMORPHISMS IN IL17AIS ASSOCIATED WITH PULMONARY TUBERCULOSIS IN BABYLON PROVINCE, IRAQ

MOHAMMED A. AL-SAADI, IFADKERIMABD AL-SHIBLY AND MUSTAFA JAWAD AL-IMARI

Abstract

Tuberculosis (TB), a disease caused 2 million death status worldwide annually and a quarter of world population latently TB infected (LTBI) with Mycobacterium tuberculosis (MTB) that usually affects the lungs and leading to severe coughing, fever, and chest pains. The polymorphism of many cytokines decreases immunity against this pathogen, IL-17A polymorphisms associated with increased risk to TB infection. To study the correlation between IL-17A polymorphism in PTB patient, PTB contact and healthy control. A case-control study with 60 PTB patients, which visit the chest and respiratory disease center in Babylon province, compared with 60 control (30 PTB contact subject and 33healthy control subject). All the DNA of study subjects was extracted to amplify IL-17A gene by specific primer designed for the purpose of IL-17A amplicon sequencing to detect SNPs. The demographic characteristics show the male more exposure to infection. the male was more frequent cases (58%) especially in age range (35-44), (65-74); while the female less frequent cases (42%) than males and most cases in the age range (15-24). The sequencing of IL-17A amplicon showed two regions have frequent genotype, the AG genotype of rs2275913 was more frequent in PTB with OR=3.5 and the G allele and GG significantly increase in PTB in both rs2275913 and rs3819025 and A allele and AA genotype was lowest frequent in PTB patient that suggest associated with TB resistant and consider protective factor. Male more exposure to pulmonary tuberculosis according to lifestyle. The AA genotype and A allele low frequency in PTB patient compared with contact and control in both gene site.

Enter your contact information below to receive full paper.
Your Name :
Email:
Phone:
City:
Cost of Full Paper: Rs.75 for Indian Nationals or $20 (USD) for international subscribers.
By clicking on Request Paper you Agree to pay the above mentioned cost per paper.
  
Journal Issues
Vol 20, Dec. Suppl. No.2, 2018
Vol 20, Issue 4, 2018
Vol 20, Dec. Suppl. Issue, 2018
Vol 20, Oct Suppl. Issue, 2018
Vol 20, Issue 3, 2018
Vol 20, Issue 2, 2018
Vol 20, Issue 1, 2018
Vol 20, Feb. Suppl. Issue, 2018
Vol 19, Issue 4, 2017
Vol 19, Nov. Suppl, Issue 2017
Vol 19, Issue 3, 2017
Vol 19, Issue 2, 2017
Vol 19, Issue 1, 2017
Vol 18, Issue 4, 2016
Vol 18, Issue 3, 2016
Vol 18, Issue 2, 2016
Vol 18, Issue 1, 2016
Vol 17, Issue 4, 2015
Vol 17, Issue 3, 2015
Vol. 17 Special Issue 2015
Vol 17, Issue 2, 2015
Vol 17, Issue 1, 2015
Vol 16, Issue 4, 2014
Vol 16, Issue 3, 2014
Vol 16, Issue 2, 2014
Vol 16, Issue 1, 2014
Vol 15, Issue 4, 2013
Vol 15, Issue 3, 2013
Vol 15, Issue 2, 2013
Vol 15 Issue 1, 2013
Vol 14, Issue 4, 2012
Vol 14, Issue 3, 2012
Vol 14, Issue 2, 2012
Vol.14, Issue 1, 2012
Vol.13, Issue 4, 2011
Vol.13, Issue 3, 2011
Vol.13, Issue 2, 2011
Vol.13, Issue 1, 2011
Vol.12, Issue 4, 2010
Vol.12, Issue 3, 2010
Vol.12, Issue 2, 2010
Vol.12, Issue 1, 2010
Vol 11, Issue 4, 2009
Vol 11, Issue 3, 2009
Vol 11, Issue 2, 2009
Vol 11, Issue 1, 2009
Vol 10, Issue 4, 2008
Vol 10, Issue 3, 2008
Vol 10, Issue 3, 2008
Vol 10, Issue 2, 2008
Vol 10, Issue 1, 2008
Vol 9, Issue 4, 2007
Vol 9, Issue 3, 2007
Vol 9, Issue 2, 2007
Vol 9, Issue 1, 2007
Vol 8, Issue 4, 2006
Vol 8, Issue 3, 2006
Vol 08, Issue 2, 2006
Vol 08, Issue 1, 2006
Vol 7 Issue 4, 2005
Vol 07, Issue 3, 2005
Vol 07, Issue 2, 2005
Vol 6 Issue 4, 2004
Vol 6 Issue 3, 2004
Vol 6 Issue 2, 2004
Vol 6 Issue 1, 2004
Vol 5 Issue 3, 2003
Vol 5 Issue 2, 2003
Vol 04, Issue 4, 2002
Vol 04, Issue 1, 2002
Vol 3 Issue 1-2, 2001
Vol 1 Issue 1-2, 2000
Vol 1 Issue 3-4, 1999
Vol 1 Issue 1-2, 1999
Looking for Past Issues? Click here to get them!!