Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 21, Issue 1, 2019; Page No.(38-45)

SYNERGISTIC EFFECT OF L-CARNITINE, OMEGA-3 WITH METFORMIN ON THE LEVEL OF APELIN-36 AND SOME HORMONES IN RABBITS INDUCED WITH DIABETES

FIRAS S. ABDUL-RAZZAK, MUSA J. MOHAMMED AND EVAN M. MUSTAFA

Abstract

The recent study is designed as a comparative study between some of the physiological and biochemical parameters by observing effects of metformin with L-carnitine and omega-3 in the blood of male rabbits induced by alloxan. The rabbits weight (1500-1800) g, aged (10-14) months were distributed into 5 group; each group included 9 rabbits as following : The control group (healthy) the second : alloxan group (infected group); the third :the lowering metformin and alloxan; the fourth : group get metformin+Lcarnitine and alloxan; the fifth: group get metformin+omega-3 and alloxan. The measured parameters included glucose, Apelin-36, insulin, glucagon, Dipeptidyl peptidase-4 (Dpp4) for the five groups. The results have shown that: 1-The induced diabetes by alloxan resulted in a significant increase in the levels of glucose and insulin, glucagon and Dpp4 when compared with the control group, and a significant decrease in the level of apelin 36 as compared with the control group. 2- The treatment of the local Rabbits exposed to diabetes by the induced lowering metformin only led to a significant increases in the levels of glucose and apelin 36 when compared with the alloxan group, and the treatment resulted in significant decrease in the levels of insulin and Dpp4 when compared with alloxan group, while there is a non - significant difference in the level of glucagon when compared with alloxan group. 3- The treatment of the local rabbits exposed diabetes by the induced lowering metformin + L-carnitine led to significant decrease in the levels of glucose, insulin when compared with the alloxan group and decrease in the level of apelin and Dpp4 when compared with the alloxan group while there is a non - significant difference in the level of glucagon when compared with alloxan group. 4-The treatment the local rabbits exposed diabetes by the induced lowering metformin + omega-3 result in a significant decrease in the levels of glucose, Insulin, glucagon and Dpp4. Whereas the treatment led to a significant increase in the levels of apelin 36 when a compared with alloxan group.

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