Harisma B.R., Lok Kirubahar S., Jenifer Annis Christy J. and Murugappan RM.
Abstract
Biologically active compounds in the latex of Calotropis procera are found to possess vital pharmacological properties in Ayurvedic toxicology and therapeutics. Therefore, multiparous biological activities such as anti-microbial, anti-inflammatory and mosquito larvicidal properties of C. procera latex was evaluated in this study. Phytochemical analysis of the freshlatex of C. procera has indicated the presence of saponins, steroids, alkaloids and terpenoids. Anti-inflammatory efficiency of the latex from C. procera was analysed by proteinase inhibitory and membrane stabilization potential and compared with the standard drug Aceclofenac. Proteinase inhibitory potential was found to be 50.22% and membran estabilization potential was found to be 75.3% at a concentration of 250 μg/ml. Antagonistic activity of the latex against pathogenic bacteria and fungi illustrates that bacteria was found to be more susceptible when compared to the fungi tested. Inhibitory efficiency was found to be concentration dependant. Larvicidal efficiency of latex was investigated against denguevector Aedes aegypti. Percent mortality of A. aegypti was directly proportional to the concentration of latex. LC50 and LC90 values of C.porcera against A. aegypti was found tobe 85.113 and 162.35 ïl/ml respectively. Morphological changes in the mosquito larva were observed on exposure to different concentration of the latex.