PALAK MOVALIYA, KRUNAL D. MEHTA, HIESH SHINGALA AND SWATI JETHAVA
Abstract
After respiratory tract infections, urinary tract infections (UTIs) are the second most common infection in the community and healthcare settings, including hospitals. Klebsiella pneumonie causes second most UTIs after Escherichia coli. This pathogen has many virulence characteristics and is producing more resistant strains, including ESBL and Carbapenem-resistant strains. These resistant infections raise morbidity, death, and healthcare expenses. In this work, Klebsiella pneumoniae is isolated from urine samples from a tertiary care hospital and assessed for antimicrobial susceptibility. A tertiary care hospital retrospective analysis included all Klebsiella pneumoniae-positive urine samples collected in sterile containers by the microbiology laboratory from July to December 2023. The positive colonies were tested for antibiotic susceptibility using Modified Kirby-Bauer disc diffusion. Over six months, 116 Klebsiella pneumoniae-containing urine samples were processed. These isolates were 74.7% aztreonam-resistant, 73.8% amoxicillin-clavulanate-resistant, and 50-60% cephalosporin-resistant. Meropenem, levofloxacin, ciprofloxacin, and ertapenem (100% sensitivity) were the most sensitive, followed by ceftazidime-avibactam (98%), nitrofurantoin (94%), and piperacillin-tazobactam (78.5%). Our investigation found substantial resistance to beta-lactam combination medicines and cephalosporins, possibly due to their frequent use. Reserve imipenem, Meropenem, or Ertapenem for hospital-acquired illnesses.