MADHVI GUPTA, MUK ESH KUMAR AND ASHISH K. ASTHANA
Abstract
The association between apolipoprotein (apo A-f& B) and vascular complication was investigated. Over 230 patients of vascular complication and their off springs (n=418) were compared with normal healthy subjects (n=100) and their children (n=122) Serum apo Al and apo-B were significantly low (p<0.05 and 0.001) and high (p<0.01 igt 0.001) respectively in children of either Mother/Father having vascular complication and children of parents both having vascular complication with children of normal healthy subjects. On comparing children of both groups with each other serum apo- Al and apo B was significantly low (p<0.001) and high (p<0.001) respectively in children of parents both having vascular complication of group A (below age 40 years). It is suggested that disease is more likely to transfer in children of parents both having vascular complication of below age 40 years. Implication of this study is that increase of apo A-I might play protective role in the pathogenesis of vascular complication.