PURWATI, BAGUS SATRIO NURWITO AND HENDITA NUR MAULIDA
Abstract
Wound healing is a complex tissue regeneration process that the body undergoes as a response to wound openings or missing cellular structures as a result of various types of traumatic injury. Because of the ability of materials to induce a high immune response or limited donor tissues, the skin repair and regeneration methods using allografts and autografts cannot be widely used. Many researches have shifted into tissue engineering approaches using scaffolds. To achieve the goal of tissue reconstruction, scaffolds must meet some specific requirements include biocompatibility, biodegradability, and mechanical properties. Our study aimed to fabricate composite cellulose acetate-collagen (CA/Collagen) scaffolds by electrospinning and determine the appropriate compositions of CA:Collagen for obtaining skin substitutes as wound dressing through investigating the morphological of stem cell seeded on electrospun CA/Collagen membranes. High proliferation of mesenchymal stem cells on electrospun CA/collagen 75:25 (wt.%) confirmed the capability of CA/collagen 75:25 nanofibers as a tissue-engineered scaffold, while the electrospun CA/collagen 75:25 can be a potential low-adherent wound dressing.