E. Wulandari, R.A.F. Hapsari, T. Bayyina and N.A. Hasanuddin
Abstract
Tumor or neoplasm, mutation can cause an increased the mass of abnormal tissue and grows excessively. It is not coordinated and grow continuously even though the stimuli was stop. Nowadays many people die due to tumors, it is a form of paramedicsâ failure. One of the methode to suppress the tumor, by using Jatropha plants (Jatropha curcas L) that known to be anti-tumor. To understand the character of these plants, we are doing a research to know is the molecular mechanisms in apoptosis (programmed cell death). Protein which plays in an important role in stimulating apoptosis are p53 (upstream) and caspase-3 (downstream). Therefore, the purpose of this study was to know the effect of Jatropha seed (Jatropha curcas L) on the apoptosis mechanisms. The jatropha extract has increased of apoptosis in hepar tissues and cause damage to the hepatocyte.