EFFECT OF A POLY-HERBAL FORMULATION, AMBREX, ON SERUM LIPID PROFILE IN ISOPROTERENOL- INDUCED MYOCARDIAL INFARCTION IN RATSREKHA RAVINDRAN ,LAVANYA P. , JAMUNA DEVI A. AND JOHANNA RAJKUMARAbstract Ambrex is a herboamber drug which is a cocktail of four indigenous herbs Withania somnifera, Orchis mascula, Cycas circirnalis and Shorearobusta with Pon amber. Sprague-Dawley male rats were pretreated with Ambrex orally at the dose levels of 40 mg/kg body weight for a period of 21 days. At the end of treatment period isoproterenol(ISO, 85 mg kg-1 body weight) was given subcutaneously to induce myocardial ischemia for 2 consecutive days at an interval of 24 hr. The cardiac lipid profile was performed in the serum .There were significant reductions in low density lipoprotein (LDL)-cholesterol levels, and significant increase (p<0.05) in high density lipoprotein (HDL) cholesterol in the treated group compared to the isoproterenol group. Biochemical alterations induced by isoproterenol were brought to normal by the administration of Ambrex. The protective effect may be due to its enhancement of endogenous antioxidant reserves, anti-hyperlipidemic, hypoglycemic and membrane stabilizing property which may contribute to its cardio protective properties. Thus it can be concluded that Ambrex possesses antioxidant activity and protects the heart from damage caused by isoproterenol.
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