INVESTIGATION OF DEOXYNIVALENOL AND ITS ASSOCIATED DISTURBANCES IN URINE CREATININEP. K. MAHESHWAR, R. NANDU, SANJAY K. R. AND CHARITH RAJ ADKAR- PURUSHOTHAMAAbstract Deoxynivalenol (DON) a mycotoxin is frequently found in cereal products consumed throughout the world. Deoxynivalenol is mainly produced by Fusarium graminearum and Fusarium culmorum. The acute symptoms associated with Deoxynivalenol ingestion are vomiting, diarrhoea abnormalities in the kidneys and gastrointestinal tract. In the present work 30 urine samples from the volunteers from different geographical regions of Southern Karnataka were obtained and subjected to the analysis through Liquid Chromatography-Mass spectrometry. Astonishgly Deoxynivalenol was detected at a concentration of 32 to 1065.9ng/mL of human urine sample and 90% of the samples analysed were positive for Deoxynivalenol. Further the urinary creatinine was also analysed which increased with the presence of Deoxynivalenol toxin in the urine samples. A high concentration of creatinine was reported that is 2.89 and 2.79 mg/dL of urine. This is the first survey for Deoxynivalenol in human urine samples from the state of Karnataka population and also the first demonstration of creatinine imbalance with an increase in Deoxynivalenol among Indian population.
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